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Workshop: AML mutation detection using error-corrected sequencing

Acute myeloid leukemia (AML) is a clonally heterogeneous cancer where the landscape of mutations is highly variable between children and adults, involving complex chromosomal translocations, indels and single nucleotide variants (SNVs). Traditional molecular assays rely upon multiple platforms to identify mutations but generally lack quantitation of rare clones. Advances in sequencing-based methods enable comprehensive detection of gene fusions, SNVs, gene expression and internal tandem duplications. From Washington University, now ArcherDX CMO, Dr. Todd Druley describes his use of error-corrected sequencing coupled with powerful bioinformatics to detect rare clonal variants in adult and pediatric AML.

Webinar: Validation of Error-Corrected Sequencing for Hematological Malignancies

In this webinar, Drs. Catherine Rehder and Sarah Rapisardo, at Duke University, describes their efforts to validate the VariantPlex® Myeloid assay. They also discuss their work to expand testing with a custom FusionPlex® assay to detect known and novel fusions, with a focus on Ph-like acute lymphoblastic leukemia (ALL) fusions.


Cecilia Yeung, MD., from Fred Hutchinson Cancer Research Center, discusses how she is using Anchored Multiplex PCR (AMP™) technology for rapid identification of fusions in leukemias with Oxford Nanopore™ real-time sequencing. This webinar was recorded on August 7, 2018.

Plasma Mutation Panel

In this AMP 2017 workshop, Dr. Margaret L. Gulley, from UNC School of Medicine, describes her ability to confidently detect variants and viral markers in plasma DNA using targeted NGS coupled with powerful bioinformatics.

FLT3-ITD Detection With Blood Cancer Assays

The molecular landscape of leukemia and lymphoma has expanded exponentially in the last two decades, and the complexity and scope of biomarkers makes molecular analysis difficult for any single approach. FusionPlex® and VariantPlex® assays are powered by Anchored Multiplex PCR (AMP™) target enrichment chemistry to detect multiple mutation types and gene expression profiling in a single sample.

Why RNA is Better for Fusion Detection

Why do FusionPlex® assays use RNA instead of DNA for input material? It all comes down to biological relevance, cost, and turn-around time. See why RNA is better for fusion detection than DNA-based hybrid capture techniques.

AMP™ is Better: Strand Specificity

See how Anchored Multiplex PCR (AMP™) chemistry is better than traditional opposing primer-based enrichment, because strand-specific priming allows you to identify and correct for deamination events that would otherwise lease to false-positive results.

FusionPlex® Anchored Multiplex PCR (AMP™) Chemistry

Learn how the FusionPlex® System utilizes Anchored Multiplex PCR (AMP™) chemistry to create target enriched RNA libraries for next-generation sequencing (NGS).

AMP™ is Better for Novel Gene Fusion Detection

Anchored Multiplex PCR (AMP™) enables the detection of targets of interest, including any known or novel fusion partners by using target-specific primers uni-directional primers, along with reverse primers, that hybridize to the sequencing adapter that is ligated to each fragment prior to amplification.

VariantPlex® Anchored Multiplex PCR (AMP™) Chemistry

Learn how the VariantPlex® system uses Anchored Multiplex PCR (AMP™), which utilizes a combination of gene specific primers and half-functional universal adapters to create target enriched DNA libraries for next generation sequencing.

Molecular Barcode Adapters

Anchored Multiplex PCR (AMP™) technology utilizes Molecular Barcode (MBC) Adapters for error correction, sample identification, de duplication, and advanced analysis in targeted sequencing NGS applications.

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